|
KMID : 0605620130200040136
|
|
Journal of Korean Society of Biological Psychiatry
2013 Volume.20 No. 4 p.136 ~ p.143
|
|
|
Attunement Disorder : A Disorder of Brain Connectivity
|
|
Kim Ki-Won
Park Kyung-Min
Jang Hye-ryeon
Lee Yu-sang
Park Seon-Cheol
|
|
|
Abstract
|
|
|
Objectives: We reviewed cellular and synaptic dysconnectivity, disturbances in micro- and macro- circuitries, and neurodevelopmentally-derived disruptions of neural connectivity in the pathogenesis of schizophrenia.
Method: We reviewed the selected articles about disturbances in neural circuits which had been proposed as a pathogenetic mechanism of schizophrenia.
Results: The literature review reveals that schizophrenia may be a disease related to disturbance in neurodevelopmental mechanism, shown as ’a misconnection syndrome of neural circuit or neural network’. In descriptive psychopathological view, definition of a disorder of brain connectivity has limitation to explain other aspects of schizophrenia including deterministic strictness in thought process.
Conclusion: Schizophrenia is considered as a disorder of brain connectivity as well as a neurodevelopmental disorder related with genetic and environmental factors. We could make a suggestion that "JoHyeonByung (attunement disorder)" denotes the disturbances of psychic fine-tuning which correspond to the neural correlates of brain dysconnectivity metaphorically.
|
|
|
KEYWORD
|
|
|
Schizophrenia, Brain connectivity, Neurodevelopment
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|